Bosutinib

Product Specifications

CAS Number

380843-75-4

Synonyms

SKI-606

Target

Src

Applications

Protein Tyrosine Kinase

Smiles

CN1CCN (CC1) CCCOC2=C (C=C3C (=C2) N=CC (=C3NC4=CC (=C (C=C4Cl) Cl) OC) C#N) OC

Molecular Formula

C26H29Cl2N5O3

Additionnal Information

Bosutinib is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM in cell-free assays, respectively. Bosutinib also effectively decreases the activity of PI3K/AKT/mTOR, MAPK/ERK and JAK/STAT3 signaling pathways by blocking the phosphorylation levels of p-ERK, p-S6, and p-STAT3. Bosutinib promotes autophagy.