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IQ 3

Product Specifications

CAS Number

312538-03-7

Target

Interleukins

Applications

Immunology & Inflammation

Smiles

C1=CC=C2C (=C1) C3=NC4=CC=CC=C4N=C3C2=NOC (=O) C5=CC=CO5

Molecular Formula

C20H11N3O3

Additionnal Information

IQ 3 is a specific c-Jun N-terminal kinase (JNK) inhibitor with Kd of 66 nM, 240 nM and 290 nM for JNK3, JNK1 and JNK2, respectively. IQ 3 inhibits LPS-induced NF-κB/AP1 transcriptional activity in THP1-Blue cells with IC50 of 1.4 μM. IQ 3 also inhibits TNF-α and IL-6 production in vitro.

Storage Conditions

3 years -20°C powder

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