IQ 3
Product Specifications
CAS Number
312538-03-7
Target
Interleukins
Applications
Immunology & Inflammation
Smiles
C1=CC=C2C (=C1) C3=NC4=CC=CC=C4N=C3C2=NOC (=O) C5=CC=CO5
Molecular Formula
C20H11N3O3
Additionnal Information
IQ 3 is a specific c-Jun N-terminal kinase (JNK) inhibitor with Kd of 66 nM, 240 nM and 290 nM for JNK3, JNK1 and JNK2, respectively. IQ 3 inhibits LPS-induced NF-κB/AP1 transcriptional activity in THP1-Blue cells with IC50 of 1.4 μM. IQ 3 also inhibits TNF-α and IL-6 production in vitro.
Storage Conditions
3 years -20°C powder
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