Auristatin E
Product Specifications
CAS Number
160800-57-7
Target
Others
Applications
Others
Smiles
CC (C) [C@H] (N (C) C) C (N[C@H] (C (N ([C@@H] ([C@@H] (C) CC) [C@@H] (CC (N1CCC[C@@]1 ([H]) [C@H] (OC) [C@@H] (C) C (N[C@H] (C) [C@H] (C2=CC=CC=C2) O) =O) =O) OC) C) =O) C (C) C) =O
Molecular Formula
C40H69N5O7
Additionnal Information
Auristatin E (AE) is a fully synthetic, highly potent antimitotic pentapeptide and a structural analog of dolastatin-10. It inhibits microtubule polymerization, leading to mitotic arrest at the G2/M phase and subsequent apoptotic cell death in tumor cells. Due to its high toxicity, AE is primarily utilized as a cytotoxic payload in antibody–drug conjugates (ADCs), where targeted delivery minimizes systemic toxicity.
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