HSP90-IN-22
Product Specifications
UNSPSC Description
HSP90-IN-22 (Compound 35) is an Hsp90 inhibitor with antiproliferative properties on cells with IC50 values of 3.65 μM for MCF7 breast cancer cells and 2.71 μM for SKBr3 breast cancer cells, respectively.
Target Antigen
HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hsp90-in-22.html
Solubility
DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C(C1=CC=C(C(OC)=C1)OC)NC2=CC3=C(N=C(N4CCN(CC4)CC)C=C3C)C=C2
Molecular Weight
434.53
References & Citations
[1]Jiang F, et al. Identification and optimization of novel 6-acylamino-2-aminoquinolines as potent Hsp90 C-terminal inhibitors. Eur J Med Chem. 2017 Dec 1;141:1-14.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-153588/HSP90-IN-22-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-153588/HSP90-IN-22-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
442898-75-1
Available Sizes
Curated Selection
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