What is the catalog number for XYD049?

The catalog number for XYD049 is E5854-5mg.

What sizes are available for XYD049?

XYD049 is available in the following size(s): 5 mg.

XYD049 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures XYD049?

XYD049 is manufactured by Bimake.

What is the estimated delivery time for XYD049?

Estimated delivery time for XYD049 is approximately 15 business day(s), depending on your location.

XYD049

Product Specifications

CAS Number

3006788-11-7

Smiles

CC1=NOC2=CC (OCC (NCCCCCNC3=CC=CC (C (N4C5CCC (NC5=O) =O) =O) =C3C4=O) =O) =C (C=C21) NS (C6=C (C=CC (Br) =C6) OC) (=O) =O

Molecular Formula

C35H35BrN6O10S

Additionnal Information

XYD049 (compound 7d) is a CRBN-based molecular glue targeting GSPT1 (DC50=19 nM), applicable for studying MYC-driven castration-resistant prostate cancer (CRPC) . It demonstrates potent growth inhibition of 22Rv1 cells (IC50=7 nM) and exhibits in vivo antitumor activity. XYD049 downregulates CRPC-associated oncogenes (AR, AR-v7, PSA, c-Myc) in 22Rv1 cells. Structurally, it consists of: 1) a molecular glue linker (NH2-C5-NH-Boc), 2) a CRBN-recruiting E3 ligase ligand (Thalidomide 4-fluoride), and 3) a GSPT1-targeting moiety (GSPT1 ligand-1) . The E3 ligase ligand-linker combination forms conjugate 158.