Ensifentrine
Product Specifications
CAS Number
1884461-72-6
Synonyms
RPL-554
Target
PDE
Applications
Metabolism
Molecular Formula
C26H31N5O4
Additionnal Information
Ensifentrine (RPL-554) is a first-in-class dual inhibitor of phosphodiesterase 3 (PDE3) and PDE4 with IC50 values of 0.4 nM and 1479 nM, respectively. Ensifentrine also inhibits lipopolysaccharide-induced tumor necrosis factor alpha release from human monocytes in a concentration-dependent manner. Ensifentrine demonstrates bronchoprotective and anti-inflammatory activities and can be used for chronic obstructive pulmonary disease (COPD) research.
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