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Barbadin

Product Specifications

CAS Number

356568-70-2

Target

Apoptosis

Applications

0

Smiles

O=C1C (C (C2=CC=C (CC3=CC=CC=C3) C=C2) =CS4) =C4N=CN1N

Molecular Formula

C19H15N3OS

Additionnal Information

Barbadin is a selective β-arrestin/β2-adaptin interaction inhibitor with IC50 values of 19.1 μM (β-arrestin1) and 15.6 μM (β-arrestin2) . It inhibits agonist-induced endocytosis of β2-adrenergic, V2-vasopressin, and angiotensin-II type-1 receptors. Additionally, Barbadin exhibits pro-apoptotic activity.

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