Venadaparib (IDX-1197)
Product Specifications
CAS Number
1681017-83-3
Target
PARP
Applications
DNA Damage/DNA Repair
Smiles
FC1=C (C=C (CC2=NNC (=O) C3=CC=CC=C23) C=C1) C (=O) N4CC (CNC5CC5) C4
Molecular Formula
C23H23FN4O2
Additionnal Information
Venadaparib (IDX-1197), a potent PARP1/2 inhibitor with IC50 values of 1.4 nM and 1.0 nM respectively, prevents the repair of DNA single-strand breaks (SSB) and promotes the conversion of SSB to double-stranded breaks (DSB), which ultimately leads to synthetic lethality in cancer cells.
Storage Conditions
3 years -20°C powder
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