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MLi-2

Product Specifications

CAS Number

1627091-47-7

Target

LRRK2

Applications

Autophagy

Smiles

CC1CN (CC (C) O1) C2=CC (=NC=N2) C3=N[NH]C4=CC=C (OC5 (C) CC5) C=C34

Molecular Formula

C21H25N5O2

Additionnal Information

MLi-2 is an orally active and highly selective inhibitor of LRRK2. MLi-2 exhibits exceptional potency in a purified LRRK2 kinase assay in vitro with IC50 of 0.76 nM, a cellular assay monitoring dephosphorylation of LRRK2 pSer935 LRRK2 with IC50 of 1.4 nM, and a radioligand competition binding assay with IC50 of 3.4 nM.

Storage Conditions

3 years -20°C powder

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