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Remibrutinib

Product Specifications

CAS Number

1787294-07-8

Synonyms

LOU064

Target

Interleukins

Applications

Immunology & Inflammation

Smiles

CC1=C (C=C (C=C1NC (=O) C2=C (C=C (C=C2) C3CC3) F) F) C4=C (C (=NC=N4) N) OCCN (C) C (=O) C=C

Molecular Formula

C27H27F2N5O3

Additionnal Information

Remibrutinib is a potent, highly selective covalent inhibitor of bruton tyrosine kinase (BTK) with IC50 of 1.3 nM, 2.5 nM and 18 nM for BTK, FcγR-induced IL8 and anti-IgM/IL4-induced CD69, respectively. Remibrutinib (LOU064) exhibits an exquisite kinase selectivity due to binding to an inactive conformation of BTK and has the potential for the treatment of autoimmune diseases.

Storage Conditions

3 years -20°C powder

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