ACBI1

CC1=C (SC=N1) C2=CC (=C (CNC (=O) C3CC (O) CN3C (=O) C (NC (=O) C4 (F) CC4) C (C) (C) C) C=C2) OCCOC5=CC=C (CN6CCN (CC6) C7=C (N) N=NC (=C7) C8=C (O) C=CC=C8) C=C5

ACBI1 is a potent and cooperative PROTAC degrader of SMARCA2, SMARCA4 and PBRM1 with DC50 of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 induces anti-proliferative effects and apoptosis.