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Homoharringtonine (HHT)

Product Specifications

CAS Number

26833-87-4

Synonyms

CGX-635, Myelostat, NSC 141633

Target

STAT

Applications

Apoptosis

Smiles

CC (C) (CCCC (CC (=O) OC) (C (=O) OC1C2C3=CC4=C (C=C3CCN5C2 (CCC5) C=C1OC) OCO4) O) O

Molecular Formula

C29H39NO9

Additionnal Information

Homoharringtonine (HHT), a plant alkaloid with antitumor properties, inhibits protein translation by preventing the initial elongation step of protein synthesis via an interaction with the ribosomal A-site. Homoharringtonine reversiblely inhibits IL-6-induced STAT3 Tyrosine 705 phosphorylation and reduced anti-apoptotic proteins expression.

Storage Conditions

3 years -20°C powder

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