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BO-264

Product Specifications

CAS Number

2408648-20-2

Target

TACC3

Applications

Cytoskeletal Signaling

Smiles

COC1=CC=C (C=C1) C2=NOC (=C2) NC3=NC (=NC=C3) N4CCOCC4

Molecular Formula

C18H19N5O3

Additionnal Information

BO-264 is a potent and orally active inhibitor of transforming acidic coiled-coil 3 (TACC3) with IC50 of 188 nM and Kd of 1.5 nM. BO-264 specifically blocks the function of FGFR3-TACC3 fusion protein. BO-264 induces SAC-dependent mitotic arrest, apoptosis and DNA damage with antitumor activities.

Storage Conditions

3 years -20°C powder

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