What is the catalog number for HLM006474?

The catalog number for HLM006474 is S8963-5mg.

What sizes are available for HLM006474?

HLM006474 is available in the following size(s): 5 mg.

Is HLM006474 in stock?

HLM006474 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures HLM006474?

HLM006474 is manufactured by Bimake.

What is the estimated delivery time for HLM006474?

Estimated delivery time for HLM006474 is approximately 15 business day(s), depending on your location.

HLM006474

Product Specifications

CAS Number

353519-63-8

Target

CDK

Applications

Cell Cycle

Smiles

CCOC1=C (C=C (C=C1) C (C2=C (C3=C (C=CC (=N3) C) C=C2) O) NC4=CC=CC=N4) C

Molecular Formula

C25H25N3O2

Additionnal Information

HLM006474 is a small molecule pan-E2F inhibitor that inhibits DNA binding to E2F4 with IC50 of 29.8 μM in A375 cells. HLM006474 induces a reduction in cell proliferation and an increase in apoptosis. The CDK/Rb/E2F pathway is commonly disrupted in lung cancer, and HLM006474 is shown to have efficacy in lung cancer.