HLM006474
Product Specifications
CAS Number
353519-63-8
Target
CDK
Applications
Cell Cycle
Smiles
CCOC1=C (C=C (C=C1) C (C2=C (C3=C (C=CC (=N3) C) C=C2) O) NC4=CC=CC=N4) C
Molecular Formula
C25H25N3O2
Additionnal Information
HLM006474 is a small molecule pan-E2F inhibitor that inhibits DNA binding to E2F4 with IC50 of 29.8 μM in A375 cells. HLM006474 induces a reduction in cell proliferation and an increase in apoptosis. The CDK/Rb/E2F pathway is commonly disrupted in lung cancer, and HLM006474 is shown to have efficacy in lung cancer.
Storage Conditions
3 years -20°C powder
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
GTR10360765 96 Well
Goat Collagen Alpha 2 (IV) chain (COL4A2) ELISA Kit
Sign In for Pricing
View Details 
K6284303 1.0 µg DNA
Vom1r38 sgRNA CRISPR Lentivector (Rat) (Target 2)
Sign In for Pricing
View Details MBS1131032-01 0.02 mg (E-Coli)
Recombinant Vibrio cholerae serotype O1 Vitamin B12-binding protein (btuF)
Sign In for Pricing
View Details MBS1131032-02 0.1 mg (E-Coli)
Recombinant Vibrio cholerae serotype O1 Vitamin B12-binding protein (btuF)
Sign In for Pricing
View Details MBS1131032-03 0.02 mg (Yeast)
Recombinant Vibrio cholerae serotype O1 Vitamin B12-binding protein (btuF)
Sign In for Pricing
View Details