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MYCi361

Product Specifications

CAS Number

2289690-31-7

Synonyms

NUCC-0196361

Target

Myc

Applications

Apoptosis

Smiles

CN1C (=CC (=N1) C (F) (F) F) C2=C (C (=C (C=C2) OCC3=CC=C (C=C3) Cl) C4=CC (=CC (=C4) C (F) (F) F) C (F) (F) F) O

Molecular Formula

C26H16ClF9N2O2

Additionnal Information

MYCi361 is a MYC inhibitor that engages MYC inside cells, disrupts MYC/MAX dimers, and impairs MYC-driven gene expression. MYCi361 binds to MYC with Kd of 3.2 μM. MYCi361 suppresses in vivo tumor growth, increases tumor immune cell infiltration, upregulates PD-L1 on tumors, and sensitizes tumors to anti-PD1 immunotherapy.

Storage Conditions

3 years -20°C powder

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