MYCi361
Product Specifications
CAS Number
2289690-31-7
Synonyms
NUCC-0196361
Target
Myc
Applications
Apoptosis
Smiles
CN1C (=CC (=N1) C (F) (F) F) C2=C (C (=C (C=C2) OCC3=CC=C (C=C3) Cl) C4=CC (=CC (=C4) C (F) (F) F) C (F) (F) F) O
Molecular Formula
C26H16ClF9N2O2
Additionnal Information
MYCi361 is a MYC inhibitor that engages MYC inside cells, disrupts MYC/MAX dimers, and impairs MYC-driven gene expression. MYCi361 binds to MYC with Kd of 3.2 μM. MYCi361 suppresses in vivo tumor growth, increases tumor immune cell infiltration, upregulates PD-L1 on tumors, and sensitizes tumors to anti-PD1 immunotherapy.
Storage Conditions
3 years -20°C powder
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