MZ-1

CC1=C (SC2=C1C (=NC (C3=NN=C (N32) C) CC (=O) NCCOCCOCCOCC (=O) NC (C (=O) N4CC (CC4C (=O) NCC5=CC=C (C=C5) C6=C (N=CS6) C) O) C (C) (C) C) C7=CC=C (C=C7) Cl) C

MZ-1 is a PROTAC degrader of bromodomain-containing protein 4 (BRD4) . MZ-1 binds to the Brd bromodomain with Kd of 62 nM, 60 nM, 21 nM, 13 nM, 39 nM and 15 nM for Brd2BD1, Brd2BD2, Brd3BD1, Brd3BD2, Brd4BD1 and Brd4BD2.