GMB-475
Product Specifications
CAS Number
2490599-18-1
Target
Bcr-Abl
Applications
Protein Tyrosine Kinase
Smiles
CC1=C (SC=N1) C2=CC=C (CNC (=O) C3CC (O) CN3C (=O) C (NC (=O) COCCOC4=CC=C (C=C4) C5=CC (=NC=N5) NC6=CC=C (OC (F) (F) F) C=C6) C (C) (C) C) C=C2
Molecular Formula
C43H46F3N7O7S
Additionnal Information
GMB-475 is a proteolysis-targeting chimera (PROTAC) that allosterically targets BCR-ABL1 protein and recruit the E3 ligase Von Hippel-Lindau (VHL), resulting in ubiquitination and subsequent degradation of the oncogenic fusion protein.
Storage Conditions
3 years -20°C powder
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