TAS0728
Product Specifications
CAS Number
2088323-16-2
Synonyms
TPC 107
Target
HER2
Applications
Protein Tyrosine Kinase
Smiles
CC1=C (C=CC (=C1C) NC (=O) C2=NN (C3=NC=NC (=C23) N) C4CCCN (C4) C (=O) C=C) CC (=O) N (C) C
Molecular Formula
C26H32N8O3
Additionnal Information
TAS0728 (TPC 107) is a potent, selective, orally active, irreversible and covalent-binding inhibitor of HER2 (human epidermal growth factor receptor 2) with IC50 of 13 nM. TAS0728 inihibits BMX, HER4, BLK, EGFR, JAK3, SLK, LOK and human HER2 with IC50 of 4.9 nM, 8.5 nM, 31 nM, 65 nM, 33 nM, 25 nM, 86 nM and 36 nM, respectively. TAS0728 shows antitumor activity.
Storage Conditions
3 years -20°C powder
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