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Unesbulin (PTC596)

Product Specifications

CAS Number

1610964-64-1

Target

BMI-1

Applications

Cell Cycle

Smiles

CC1=NC2=C (N1C3=NC (=C (C (=N3) NC4=CC=C (C=C4) C (F) (F) F) F) N) C=C (C=C2) F

Molecular Formula

C19H13F5N6

Additionnal Information

Unesbulin (PTC596) is a second-generation BMI-1 inhibitor that accelerates BMI-1 degradation. PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis. IC50 values at 72 hours ranged from 68 to 340 nM in mantle cell lymphoma (MCL) cell lines.

Storage Conditions

3 years -20°C powder

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