Unesbulin (PTC596)
Product Specifications
CAS Number
1610964-64-1
Target
BMI-1
Applications
Cell Cycle
Smiles
CC1=NC2=C (N1C3=NC (=C (C (=N3) NC4=CC=C (C=C4) C (F) (F) F) F) N) C=C (C=C2) F
Molecular Formula
C19H13F5N6
Additionnal Information
Unesbulin (PTC596) is a second-generation BMI-1 inhibitor that accelerates BMI-1 degradation. PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis. IC50 values at 72 hours ranged from 68 to 340 nM in mantle cell lymphoma (MCL) cell lines.
Storage Conditions
3 years -20°C powder
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