V-9302
Product Specifications
CAS Number
1855871-76-9
Target
Amino acid transporter
Applications
Transmembrane Transporters
Smiles
CC1=CC (=CC=C1) COC2=CC=CC=C2CN (CCC (C (=O) O) N) CC3=CC=CC=C3OCC4=CC=CC (=C4) C
Molecular Formula
C34H38N2O4
Additionnal Information
V-9302 is a competitive small molecule antagonist of transmembrane glutamine flux, that selectively and potently targets the amino acid transporter ASCT2 (SLC1A5) with an IC50 value of 9.6 μM for inhibition of glutamine uptake in HEK-293 cells. V-9302 blocks Sodium-neutral AA transporter 2 (SNAT2, SLC38A2) and the large neutral AA transporter 1 (LAT1, SLC7A5) as observed in 143B osteosarcoma cells, HCC1806 breast cancer cells and Xenopus laevis oocytes. Dilution of PBS may cause a clear aqueous solution to turn into a uniform suspension.
Storage Conditions
3 years -20°C powder
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