DBET6

Product Specifications

CAS Number

1950634-92-0

Target

Epigenetic Reader Domain

Applications

Epigenetics

Smiles

CC1=C (SC2=C1C (=NC (C3=NN=C (N32) C) CC (=O) NCCCCCCCCNC (=O) COC4=CC=CC5=C4C (=O) N (C5=O) C6CCC (=O) NC6=O) C7=CC=C (C=C7) Cl) C

Molecular Formula

C42H45ClN8O7S

Additionnal Information

DBET6 is a highly cell-permeable PROTAC degrader of BET bromodomains with an IC50 of 14 nM for BRD4 binding. dBET6 also induces c-MYC downregulation and apoptosis.

Storage Conditions

3 years -20°C powder

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