S55746
Product Specifications
CAS Number
1448584-12-0
Synonyms
S 055746, BCL201
Target
Bcl-2
Applications
Apoptosis
Smiles
C1CCN2C (=C (C=C2C3=CC4=C (C=C3C (=O) N5CC6=CC=CC=C6CC5CN7CCOCC7) OCO4) C (=O) N (C8=CC=CC=C8) C9=CC=C (C=C9) O) C1
Molecular Formula
C43H42N4O6
Additionnal Information
S55746 (S 055746, BCL201) is a novel, orally active BCL-2 specific inhibitor (Ki = 1.3 nM) with poor affinity for BCL-XL and no significant binding to MCL-1, BFL-1 (BCL2A1/A1) . The selectivity of S55746 for BCL-2 versus BCL-XL ranges from ~70 to 400 folds.
Storage Conditions
3 years -20°C powder
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