Alofanib (RPT835)
Product Specifications
CAS Number
1612888-66-0
Target
FGFR
Applications
Protein Tyrosine Kinase
Smiles
CC1=CC (=C (C=C1C2=CN=CC=C2) NS (=O) (=O) C3=CC=CC (=C3) C (=O) O) [N+] (=O) [O-]
Molecular Formula
C19H15N3O6S
Additionnal Information
Alofanib (RPT835) is a novel selective allosteric inhibitor of FGFR2 and has a dramatic inhibitory effect with IC50 <10 nM on FGF2-induced phoshphorylation of FRS2a in KATO III cells. It has no direct effect on FGF2-dependent FGFR1 and FGFR3 phosphorylation levels in either cell lines and no effects on FGF2-FGFR2 binding.
Storage Conditions
3 years -20°C powder
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TRC-D446045-1G 1 g
1-[2-(2,4-Difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole
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