Tropifexor (LJN452)
Product Specifications
CAS Number
1383816-29-2
Target
FXR
Applications
Metabolism
Smiles
C1CC1C2=C (C (=NO2) C3=CC=CC=C3OC (F) (F) F) COC4CC5CCC (C4) N5C6=NC7=C (C=C (C=C7S6) C (=O) O) F
Molecular Formula
C29H25F4N3O5S
Additionnal Information
Tropifexor (LJN452) is a novel and highly potent agonist of FXR with EC50 of 0.2 nM in HTRF assay. It shows no significant off-target activity against a broad panel of enzyme, ion channel, nuclear receptor, and GPCR (>10000-fold selectivity for FXR) .
Storage Conditions
3 years -20°C powder
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