Enitociclib (BAY 1251152)
Product Specifications
CAS Number
1610358-56-9
Synonyms
(+) -BAY-1251152
Target
CDK
Applications
Cell Cycle
Smiles
COC1=C (C=CC (=C1) F) C2=CC (=NC=C2F) NC3=NC=CC (=C3) CS (=N) (=O) C
Molecular Formula
C19H18F2N4O2S
Additionnal Information
Enitociclib (BAY 1251152) is a potent PTEFb/CDK9 inhibitor with an IC50 value of 3 nM for CDK9 and an at least 50-fold selectivity against other CDKs in enzymatic assays. BAY1251152 binds to and blocks the phosphorylation and kinase activity of CDK9, thereby preventing PTEFb-mediated activation of RNA Pol II and leading to the inhibition of gene transcription of various anti-apoptotic proteins.
Storage Conditions
3 years -20°C powder
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