Pralsetinib (BLU-667)
Product Specifications
CAS Number
2097132-94-8
Synonyms
CS 3009, Gavreto
Target
C-RET
Applications
Protein Tyrosine Kinase
Smiles
CC1=CC (=NN1) NC2=NC (=NC (=C2) C) C3CCC (CC3) (C (=O) NC (C) C4=CN=C (C=C4) N5C=C (C=N5) F) OC
Molecular Formula
C27H32FN9O2
Additionnal Information
Pralsetinib (BLU-667, CS 3009, Gavreto) is a highly potent and selective RET (c-RET) inhibitor with an IC50 of 0.4 nM for WT RET. It also demonstrates potent activity (IC50 0.4 nmol/L) against common oncogenic RET alterations, including RET (M918T) .
Storage Conditions
3 years -20°C powder
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