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Nemtabrutinib (ARQ 531)

Product Specifications

CAS Number

2095393-15-8

Synonyms

MK-1026

Target

BTK

Applications

Protein Tyrosine Kinase

Smiles

C1CC (OCC1NC2=NC=NC3=C2C (=CN3) C (=O) C4=C (C=C (C=C4) OC5=CC=CC=C5) Cl) CO

Molecular Formula

C25H23ClN4O4

Additionnal Information

Nemtabrutinib (ARQ 531, MK-1026) is an ATP-competitive tyrosine kinase inhibitor designed to target BTK with an IC50 of 0.85 nM. It also has a distinct kinase selectivity profile with strong inhibitory activity against several key oncogenic drivers from TEC, Trk and Src family kinases.

Storage Conditions

3 years -20°C powder

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