RAF709
Product Specifications
CAS Number
1628838-42-5
Target
Raf
Applications
MAPK
Smiles
CC1=C (C=C (C=N1) NC (=O) C2=CC (=CC=C2) C (F) (F) F) C3=CC (=C (N=C3) OC4CCOCC4) N5CCOCC5
Molecular Formula
C28H29F3N4O4
Additionnal Information
RAF709 is a potent inhibitor of B/C RAF kinase with almost equivalent IC50 values of 0.4 nM for B-RAF and C-RAF, showing a high level of selectivity, demonstrating greater than 99% on-target binding to BRAF, BRAFV600E, and CRAF at 1 μM and very few off-targets with DDR1 (>99%), DDR2 (86%), FRK (92%), and PDGFRb (96%), the only kinases with binding >80% at 1 μM.
Storage Conditions
2 years -80 in solvent
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TRC-E589225-5MG 5 mg
(9Beta,11Beta)-9,11-Epoxy-21-hydroxy-pregna-1,4,16-triene-3,20-dione
Sign In for Pricing
View Details 
BNC472043-100 1x 100 µL
Cytokeratin 16 (KRT16) (Suprabasal Keratinocyte Marker) (KRT16/2043R), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC472075-500 1x 500 µL
MyoD1 (Rhabdomyosarcoma Marker) (MYOD1/2075R), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC880040-500 1x 500 µL
CD35 / CR1 (E11), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC682883-100 1x 100 µL
Topoisomerase I, Mitochondrial (TOP1MT) (TOP1MT/2883R), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details