MPP dihydrochloride
Product Specifications
CAS Number
911295-24-4
Synonyms
Methylpiperidino pyrazole
Target
Estrogen/progestogen Receptor
Applications
Endocrinology & Hormones
Molecular Formula
C29H31N3O3.2ClH
Additionnal Information
Methyl-piperidino-pyrazole (MPP) dihydrochloride is a highly selective antagonist for estrogen receptor alpha (ERα), with an affinity 200 times greater than for estrogen receptor beta (ERβ) . It inhibits 17β-estradiol binding to ERα by inducing conformational changes that alter the receptor’s binding site and also increases the energy required for genistein's interaction with ERα.
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