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Selective JAK3 inhibitor 1

Product Specifications

CAS Number

1443235-95-7

Target

JAK

Applications

Angiogenesis

Smiles

CCOC (=O) C1=CNC2=NC=NC (=C12) C3=CC (=CC=C3) NC (=O) C (=C) C

Molecular Formula

C19H18N4O3

Additionnal Information

Selective JAK3 inhibitor 1 is an irreversible JAK3 inhibitor with Ki values of 0.07 nM, 320 nM, 740 nM for JAK3, JAK1 and JAK2 respectively. It is also selective over the other kinases possessing a cysteine in the same region as JAK3, such as BMX, EGFR, ITK, and BTK.

Storage Conditions

3 years -20°C powder

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