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AMG 487

Product Specifications

CAS Number

473719-41-4

Target

CXCR

Applications

GPCR & G Protein

Smiles

CCOC1=CC=C (C=C1) N2C (=O) C3=CC=CN=C3N=C2C (C) N (CC4=CC=CN=C4) C (=O) CC5=CC=C (OC (F) (F) F) C=C5

Molecular Formula

C32H28F3N5O4

Additionnal Information

AMG 487 is an orally active and selective CXC chemokine receptor 3 (CXCR3) antagonist that inhibits the binding of IP-10 (CXCL10) and ITAC (CXCL11) to CXCR3 with IC50 of 8.0 nM and 8.2 nM, respectively.

Storage Conditions

3 years -20°C powder

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