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H3B-6527

Product Specifications

CAS Number

1702259-66-2

Target

FGFR

Applications

Protein Tyrosine Kinase

Smiles

CCN1CCN (CC1) C2=CC (=C (C=C2) NC3=CC (=NC=N3) N (C) C (=O) NC4=C (C (=CC (=C4Cl) OC) OC) Cl) NC (=O) C=C

Molecular Formula

C29H34Cl2N8O4

Additionnal Information

H3B-6527 is a highly selective covalent FGFR4 inhibitor with an IC50 value of <1.2 nM and at least 250-fold selectivity over FGFR1-3 (IC50 values of 320, 1,290 and 1,060 nM respectively) .

Storage Conditions

2 years -80 in solvent

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