GNE-781
Product Specifications
CAS Number
1936422-33-1
Target
Epigenetic Reader Domain
Applications
Epigenetics
Smiles
CNC (=O) N1CCC2=C (C1) C (=N[N]2C3CCOCC3) N4CCCC5=C4C=C (C (F) F) C (=C5) C6=C[N] (C) N=C6
Molecular Formula
C27H33F2N7O2
Additionnal Information
GNE-781 (compound 19) is an orally active, highly potent and selective bromodomain inhibitor of cyclic adenosine monophosphate response element binding protein (CBP) with IC50 of 0.94 nM in TR-FRET assay. GNE-781 also inhibits BRET and BRD4 (1) with IC50 of 6.2 nM and 5100 nM, respectively. GNE-781 exhibits antitumor activity.
Storage Conditions
3 years -20°C powder
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