AZD5991
Product Specifications
CAS Number
2143010-83-5
Target
Bcl-2
Applications
Apoptosis
Smiles
CC1=C2C (=NN1C) CSCC3=NN (C (=C3) CSC4=CC5=CC=CC=C5C (=C4) OCCCC6=C (N (C7=C6C=CC (=C27) Cl) C) C (=O) O) C
Molecular Formula
C35H34ClN5O3S2
Additionnal Information
AZD5991 is a macrocyclic MCL-1 inhibitor with sub-nanomolar affinity for MCL-1 (Ki = 0.13 nM) . The binding affinity of AZD5991 is about 25-fold lower for mouse Mcl-1 vs. human Mcl-1 but only four-fold lower for rat Mcl-1.
Storage Conditions
3 years -20°C powder
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