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Selitrectinib (LOXO-195)

Product Specifications

CAS Number

2097002-61-2

Synonyms

BAY 2731954

Target

Trk receptor

Applications

Protein Tyrosine Kinase

Smiles

CC1CCC2=C (C=C (C=N2) F) C3CCCN3C4=NC5=C (C=NN5C=C4) C (=O) N1

Molecular Formula

C20H21FN6O

Additionnal Information

Selitrectinib (LOXO-195, BAY 2731954) is an orally available, highly potent, and selective TRK kinase inhibitor with low nanomolar inhibitory activity against TRKA G595R, TRKC G623R, and TRKA G667C, IC50s ranging from 2.0 to 9.8 nmol/L. It is more than 1,000-fold selective for 98% of non-TRK kinases tested.

Storage Conditions

3 years -20°C powder

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