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Linrodostat (BMS-986205)

Product Specifications

CAS Number

1923833-60-6

Synonyms

ONO-7701

Target

IDO/TDO

Applications

Metabolism

Smiles

CC (C1CCC (CC1) C2=C3C=C (C=CC3=NC=C2) F) C (=O) NC4=CC=C (C=C4) Cl

Molecular Formula

C24H24ClFN2O

Additionnal Information

Linrodostat (BMS-986205, ONO-7701) is an irreversible inhibitor of IDO1 with an IC50 of 1.7 nM. It inhibits kynurenine production with IC50 values of 1.7, 1.1 and > 2000 in human HeLa, HEK293 expressing human IDO-1 and tryptophan-2, 3-dioxygenase cell-based assays.

Storage Conditions

3 years -20°C powder

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