DCA (Sodium dichloroacetate)
Product Specifications
CAS Number
2156-56-1
Synonyms
Dichloroacetic acid, bichloroacetic acid, BCA
Target
Dehydrogenase
Applications
Metabolism
Smiles
C (C (=O) [O-]) (Cl) Cl.[Na+]
Molecular Formula
C2HCl2O2.Na
Additionnal Information
DCA (Sodium dichloroacetate), a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress Na+-K+-2Cl- cotransporter and a mitochondrial potassium-ion channel axis. Sodium dichloroacetate increases reactive oxygen species (ROS) generation, triggers apoptosis in cancer cells, and inhibits tumor growth.
Storage Conditions
2 years -80 in solvent
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