Omarigliptin (MK-3102)
Product Specifications
CAS Number
1226781-44-7
Target
DPP
Applications
Metabolism
Smiles
CS (=O) (=O) N1C=C2CN (CC2=N1) C3CC (C (OC3) C4=C (C=CC (=C4) F) F) N
Molecular Formula
C17H20F2N4O3S
Additionnal Information
Omarigliptin (MK-3102) is a competitive, reversible inhibitor of DPP-4 (IC50 = 1.6 nM, Ki = 0.8 nM) . It is highly selective over all proteases tested (IC50 > 67 μM), including QPP, FAP, PEP, DPP8, and DPP9 and has weak ion channel activity (IC50 > 30 μM at IKr, Caγ1.2, and Naγ1.5) .
Storage Conditions
2 years -80 in solvent
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