Avapritinib

Product Specifications

CAS Number

1703793-34-3

Synonyms

BLU-285

Target

PDGFR

Applications

Protein Tyrosine Kinase

Smiles

CC (C1=CC=C (C=C1) F) (C2=CN=C (N=C2) N3CCN (CC3) C4=NC=NN5C4=CC (=C5) C6=CN (N=C6) C) N

Molecular Formula

C26H27FN10

Additionnal Information

Avapritinib is a small molecule kinase inhibitor that potently inhibits PDGFRα D842V mutant activity in vitro (IC50 = 0.5 nM) and PDGFRα D842V autophosphorylation in the cellular setting (IC50 = 30 nM) ; also a potent inhibitor of the analogous Kit (c-Kit) mutation, D816V in Kit (c-Kit) Exon 17 (IC50 = 0.5 nM) .