Tapotoclax (AMG-176)
Product Specifications
CAS Number
1883727-34-1
Synonyms
Tapotoclax, Tapotoclaxum
Target
Bcl-2
Applications
Apoptosis
Smiles
CC1CC=CC (C2CCC2CN3CC4 (CCCC5=C4C=CC (=C5) Cl) COC6=C3C=C (C=C6) C (=O) NS (=O) (=O) C1C) OC
Molecular Formula
C33H41ClN2O5S
Additionnal Information
Tapotoclax (AMG-176) is a potent, selective, and orally bioavailable macrocyclic inhibitor of MCL1 with a Ki of 0.13 nM. It induces a potent apoptosis in models of hematologic malignancies.
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