ARV-771

CC1=C (SC2=C1C (=NC (C3=NN=C (N32) C) CC (=O) NCCOCCCOCC (=O) NC (C (=O) N4CC (CC4C (=O) NC (C) C5=CC=C (C=C5) C6=C (N=CS6) C) O) C (C) (C) C) C7=CC=C (C=C7) Cl) C

ARV-771 is a potent pan- (bromodomain and extra-terminal) BET degrader, a novel BET-PROTAC (proteolysis-targeting chimera) with Kd of 34 nM, 4.7 nM, 8.3 nM, 7.6 nM, 9.6 nM, and 7.6 nM for BRD2 (1), BRD2 (2), BRD3 (1), BRD3 (2), BRD4 (1), and BRD4 (2), respectively.