KG-501

Product Specifications

CAS Number

18228-17-6

Synonyms

2-naphthol-AS-E-phosphate

Target

Epigenetic Reader Domain

Applications

Epigenetics

Smiles

C1=CC=C2C=C (C (=CC2=C1) C (=O) NC3=CC=C (C=C3) Cl) OP (=O) (O) O

Molecular Formula

C17H13ClNO5P

Additionnal Information

KG-501 is a cAMP response element-binding protein (CREB) inhibitor that disrupts CREB-dependent transcription (Ki = 10 μM) and CREB:CBP interaction (Ki = 50 μM) . It also disrupts phospho (Ser-133) CREB binding to KIX with a Ki of ≈90 μM, using concentrations of CREB that were within the linear range of the binding assay.