Mivebresib (ABBV-075)

Product Specifications

CAS Number

1445993-26-9

Target

Epigenetic Reader Domain

Applications

Epigenetics

Smiles

CCS (=O) (=O) NC1=CC (=C (C=C1) OC2=C (C=C (C=C2) F) F) C3=CN (C (=O) C4=C3C=CN4) C

Molecular Formula

C22H19F2N3O4S

Additionnal Information

Mivebresib (ABBV-075) is a novel BET family bromodomain inhibitor. It binds bromodomains of BRD2/4/T with similar affinities (Ki of 1-2.2 nM) and highly selective for 18 bromodomain proteins tested (Kd > 1 μM; more than 600-fold selectivity vs. BRD4), but exhibits roughly 10-fold weaker potency towards BRD3 (Ki of 12.2 nM) and has moderate activity towards CREBBP (Kd = 87 μM; 54-fold selectivity vs. BRD4) . Mivebresib (ABBV-075) efficiently triggers apoptosis in various tumor cell.