TAK-243 (MLN7243)
Product Specifications
CAS Number
1450833-55-2
Target
E1 Activating
Applications
Ubiquitin
Smiles
N[S; v6] (=O) (=O) OCC1CC (NC2=CC=NC3=CC (=N[N]23) C4=CC (=CC=C4) SC (F) (F) F) C (O) C1O
Molecular Formula
C19H20F3N5O5S2
Additionnal Information
TAK-243 (MLN7243) is a potent, mechanism-based small-molecule inhibitor of the ubiquitin activating enzyme (UAE) with an IC50 of 1 ± 0.2 nM in the UBCH10 E2 thioester assay. It has minimal inhibitory activity in a panel of kinase and receptor assays, as well as on human carbonic anhydrase type I and type II. TAK-243 (MLN7243) induces ER stress, abrogates NFκB pathway activation and promotes apoptosis.
Storage Conditions
3 years -20°C powder
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