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PF-06409577

Product Specifications

CAS Number

1467057-23-3

Target

AMPK

Applications

PI3K/Akt/mTOR

Smiles

C1CC (C1) (C2=CC=C (C=C2) C3=C (C=C4C (=C3) C (=CN4) C (=O) O) Cl) O

Molecular Formula

C19H16ClNO3

Additionnal Information

PF-06409577 is an orally bioavailable AMPK activator with EC50 of 7 nM for α1β1γ1 in the TR-FRET assay and it shows no detectable inhibition of hERG in a patch-clamp assay (100 μM) and was not an inhibitor (IC50 > 100 μM) of the microsomal activities of major human cytochrome P450 isoforms.

Storage Conditions

2 years -80 in solvent

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