GSK583
Product Specifications
CAS Number
1346547-00-9
Target
RIP kinase
Applications
Apoptosis
Smiles
CC (C) (C) S (=O) (=O) C1=CC2=C (C=CN=C2C=C1) NC3=NNC4=C3C=C (C=C4) F
Molecular Formula
C20H19FN4O2S
Additionnal Information
GSK583 is a highly potent and selective inhibitor of RIP2 kinase with IC50 of 5 nM. GSK583 also inhibits both TNF-α and IL-6 production with IC50 of ~200 nM in explant cultures.
Storage Conditions
2 years -80 in solvent
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